Moderators: 

• Sean M. Tutton, MD, FSIR, FCIRSE
• Dan TD Nguyen, MD, FASSR

Faculty: 

• Sean M. Tutton, MD, FSIR, FCIRSE | Evaluation and Physical Examination of Cancer Patients with Pain
  • Learning Objectives:
    • Define the scope of the problem
    • Discuss how pain effects cancer treatment and patient care options as well as opioid risks long term
    • Discuss WHO guidelines for pharmacologic/radiotherapy management)
    • Discuss most common areas of cancer related pain
    • Discuss techniques to evaluate and isolate the source of pain
    • Differentiating between different sources of pain (i.e. – bone, nerve, soft tissue)

• Ahmad Parvinian, MD | Anatomic and Imaging Evaluation of Cancer Specific Pain
  • Learning Objectives
    • Focus on what the physician needs to know for treatment planning
    • Demonstrate cases where different metastatic lesions affecting adjacent structures causing pain
    • Discuss optimal imaging strategies for delineating pain and potential complications of image-guided therapy

• Dan TD Nguyen, MD, FASSR | What Standardized Evaluation Systems Should I be Using in My Clinic and Current Guidelines for Pain Management?
  • Learning Objectives:
    • Discuss the current evaluation systems I can implement in my clinical evaluation of pain and templates I can implement in my clinic
    • Discuss the current NCCN guidelines for cancer related pain
    • How to optimally build a pain and palliation practice

• Junjian Huang, MD | What Happens to the Nerve during Ablation, and What Should I be Worried About? 
  • Learning Objectives:
    • Basic understanding of nerve related pain
    • Response of the nerve to cryoablation, and recovery after thermal injury
    • What are the trade-offs for alleviating pain

Moderators: 

• Dimitrios Filippiadis, MD, PhD, MSc, EBIR
• Sean M. Tutton, MD, FSIR, FCIRSE

Faculty: 

• Dimitrios Filippiadis, MD, PhD, MSc, EBIR | Nerve Ablation and Injections in Cancer Patients 
  • Learning Objectives:
    • Discuss neurolysis for non-users(Nerve, Joint, Intraarticular Injections)
    • Discuss indications of nerve injections for pain in cancer patients
    • Discuss nerve injections in non- pain related indications 

• David Prologo, MD, FSIR | Building a Cancer Related Pain Intervention Service
  • Learning Objectives:
    • How to start and develop a cancer related pain practice
    • How to market and impliment a pump and stiumlator program
    • Identify major procedural offerings and how to generate referrals

• Allan L. Brook, MD, FACR, FSIR, FASSR | Intrathecal Pumps for Cancer Pain 
  • Learning Objectives: 
    • Discuss technical components of how you do it
    • Discuss technical components of how you set up the practice
    • Discuss basic indications for intrathecal pumps 

• J. Dana Dunleavy, MD | Spinal Cord Stimulation for Cancer Pain 
  • Learning Objectives:
    • Discuss technical components of how you do it
    • Discuss technical components of how you set up the practice
    • Discuss basic indications for intrathecal pumps 

• Ashley M. Rogers, MD | Medical Management of Cancer Related Pain
  • Learning Objectives:
    • Discuss medical management options prior to procedures
    • Commonly used medications in cancer related pain and mechanisms of action
    • When to consider intervention as well as post treatment options for patients with persistent or post-procedural pain after image guided therapy

Moderators: 

• Gina Landinez, MD
• Francois H Cornelis, MD, PhD

Faculty: 

• Anthony Tadros, MD | Case Based Evaluation of Cancer Related Pelvic Pain 
  • Learning Objectives:
    • Weight bearing acetabular lesion
    • Sacral Lesion
    • Pelvic Floor Mass requiring pudendal nerve ablation

• Marwan Moussa, MD | Nerve Ablation for Cancer Related Pain Relief
  • Learning Objectives:
    • Discuss technical details of nerve thermal ablation for new users (how to do it, settings, basic approaches- can focus on common applications)
    • Discuss when this can help post-surgical patients such as hysterectomy, biliary, thoracotomy associated pain
    • Discuss the data for nerve ablation in cancer related pain for common indications

• Alexis Kelekis, MD, PhD, FSIR, FCIRSE | Case Based Evaluation of Spine Pain
  • Learning Objectives:
    • Vertebral body lesion treatment
    • Posterior element lesion treatment
    • Use spinal implants

Moderators: 

• Matthew Scheidt, MD, FSIR
• Dan TD Nguyen, MD, FASSR

Faculty: 

• Resten Imaoka, MD | Case Based Evaluation of Upper Extremity Pain  
  • Learning Objectives:
    • Cervical Spine Lesion
    • Brachial Plexus
    • Upper Extremity

• Matthew Scheidt, MD, FSIR | Case Based Evaluation of Lower Extremity Pain 
  • Learning Objectives:
    • Lumbar or Sacral Lesion with foraminal involvement
    • Lumbosacral plexus/Sciatic Notch Lesions
    • Lower Extremity Lesions

• Dan TD Nguyen, MD, FASSR | Case Based Evaluation of Pumps and Stimulator 
  • Learning Objectives:
    • Case best for targeted delivery/pain pump
    • Case best for dorsal column stimulator
    • Demonstrate cases related to the assigned topic focusing on the technical components of performing the procedure

Moderators: 

• Rony Avritscher, MD, FSIR
• Terence P. Gade, MD, PhD

Faculty: 

• Rony Avritscher, MD, FSIR | Opening Remarks & Masterclass Overview
• Terence P. Gade, MD, PhD | How to Start a Lab and Negotiate Your Package: the Story of the PIGI Lab
  • Learning Objectives:
    • Summarize how to start a lab as an early investigator
    • Describe the origins of the pigi lab from where it started to current status
    • Describe monetary considerations when starting a lab as an early career investigator

• Khashayar Farsad, MD | Rodent Models in Interventional Oncology: Unlocking Mechanisms and Enabling High-Throughput Hypothesis Testing
  • Learning Objectives:
    • Discuss advantages and challenges of small animal models
    • Review considerations in model selection for specific research questions 

• Luke Wilkins, MD, FSIR | Large Animal Models in Interventional Oncology: Bridging the Gap to Clinical Application and Advancing Device Development
  • Learning Objectives:
    • Identify roles of large animal models in IO research
    • Latest advances in development of Oncopig and updates on woodchuck model

Moderators: 

• Lynn Savic, MD
• S. Nahum Goldberg, MD, FSIR, FCIRSE

Faculty: 

• Glauco Souza, MD | 2D and 3D Culture Models: Applications in Testing Combination Approaches
  • Learning Objectives:
    • Describe techniques to screen IO agents in Vitro
    • Development of patient-derived cell lines, tumor organoids and bioprinted tumor models for personalizing treatment parameters

• Lynn J. Savic, MD | Immunological Consequences of Thermal Ablation & Endovascular Therapy
  • Learning Objectives:
    • Describe how various ablative modalities affect tumor antigen presentation and immune cell recruitment
    • Discuss existing data on use of ablation in combination therapies 

• Christopher D. Malone, MD | Potentiating the Efficacy of Endovascular Locoregional Therapy: Enabling Synergy and Overcoming Resistance
  • Learning Objectives:
    • Cellular response to hypoxia following embolization and potential combinatorial approaches

• S. Nahum Goldberg, MD, FSIR, FCIRSE; Khashayar Farsad, MD; Bradford J. Wood, MD; Lynn J. Savic, MD | ROUNDTABLE DISCUSSION: Bridging the Preclinical-Clinical Divide
  • Learning Objectives:
    • Discussion on improving translational relevance of animal models and accelerating bench-to-bedside development
    • Integrating biological insights into procedural planning and device development

Moderators: 

• Michael C. Soulen, MD, FSIR, FCIRSE
• Irene Bargellini, MD, Prof

Faculty: 

• Kristy Brock, PhD | From Bench to First-in-Human: Navigating the Regulatory Landscape
  • Learning Objectives:
    • Describe the basics of the current regulatory pathways for IR oncology devices and procedures

• Michael C. Soulen, MD, FSIR, FCIRSE | Endpoints That Matter: Selection of Clinically Meaningful Outcomes in IO Trials
  • Learning Objectives:
    • Describe trial design – with particular focus on the evolution of endpoints in cancer trials from response rates to patient-reported outcomes and survival metrics

• Nicholas J. Seewald, PhD | Statistical Considerations for IO-Specific Trial Designs
  • Learning Objectives:
    • Describe how to plan trials and what to consider regarding the specific trial design and for IR oncology studies

• Michael C. Soulen, MD, FSIR, FCIRSE; Irene Bargellini, MD, Prof; Richard S. Finn, MD | ROUNTABLE DISCUSSION: Addressing Challenges in IO Trial Design
  • Learning Objectives:
    • Interactive discussion on practical solutions to common methodological challenges

Moderators: 

• Jens Ricke, MD
• Philippe Pereira, MD

Faculty: 

• Jens Ricke, MD | Rational Design of IO-Immunotherapy Combinations
  • Learning Objectives:
    • Identify barriers to combinations specific to IO procedures (focus HCC and one other Ca if topic is to broad)
    • Describe technical considerations for trials in combination therapies

• Liliana Violante, MD | Theranostic Approaches: Combined Diagnostic and Radioembolization
  • Learning Objectives:
    • Discuss idea of next- generation radioembolization devices
    • Discuss whether there a future convergence between these different concepts

• Amy Deipolyi, MD, PhD, FSIR | Critical Gaps in Clinical Data: Looking Toward the Future
  • Learning Objectives:
    • Identify priorities for future IO trials
    • Identify short term (1-3 year), mid term (3-6 year), and long term (6-10 year) achievable goals for the IO community to engage with

• All Faculty | ROUNDTABLE DISCUSSION: Evolving Trial Evidence and Clinical Practice Changes
  • Learning Objectives:
    • How recent trial results should influence current treatment algorithms and future research directions

Moderators: 

• Isabel G. Newton, MD, PhD
• Julius Chapiro, MD, PhD
• Muneeb Ahmed, MD, FSIR

Faculty: 

• Isabel G. Newton, MD, PhD | Abscopal Effects: Facts and Fiction
  • Learning Objectives:
    • Define criteria for abscopal effect in local therapies
    • Critically discuss the existing evidence regarding abscopal effect in the literature and its implications

• Julius Chapiro, MD, PhD | Integrating Machine Learning into Future Trials For Embolotherapies
  • Learning Objectives:
    • Describe specific advances in imaging analysis and machine learning for embolotherapies
    • Identify opportunities to integrate these concepts into future clinical trials

• Jason Chiang, MD, PhD | The Role of LRT in Emerging Biological Therapies for Cancer
  • Learning Objectives:
    • Identify technical advantages of image-guided and endovascular approaches in local delivery of biological payloads
    • Describe opportunities to improve the efficacy of next generation cancer therapies through locoregional delivery

• Jens Ricke, MD | Trial Failures: What Have We Learned?
  • Learning Objectives:
    • Discuss trial design analysis of these recent landmark trials – speaker can decide which on trials to focus however should engage the audience in both positive and negative trials where critical analysis can be performed rather than a broad overview of every trial recently done
    • Describe or identify trials design flaws in chosen landmark trials that led to desirable or less than desirable outcome

• Muneeb Ahmed, MD, FSIR | ROUNDTABLE DISCUSSION: Clinical Integration of Novel Technologies
  • Learning Objectives: 
    • Discussion on implementation strategies for new devices

• Glauco Souza, PhD, MBA | ROUNDTABLE DISCUSSION: From Concept to Commercialization
  • Learning Objectives:
    • Discussion with symposium attendees and faculty on challenges and opportunities for clinical implementation of emerging tools

Title: Push The Boundaries of Interventional Oncology Through Imaging Innovations

Moderator: 

• Sean M. Tutton, MD FSIR, FCIRSE

Faculty: 

• Muneeb Ahmed, MD, FSIR