HCC Webinar 2: Emerging Evidence and Real-World Sequencing — Translating Trials to Multidisciplinary Practice

Title: Emerging Evidence and Real-World Sequencing — Translating Trials to Multidisciplinary Practice

Format: CME-eligible | 3 lectures (~15 min each) + moderated panel discussion (~30 min) | On-demand 

Recording Date: September 22, 7-8:30 PM ET  
Duration: 60 minutes 

Moderator: Robert Lewandowski, MD, FSIR

Speakers: 

James Harding, MD (Medical Oncology)

Lindsay Thornton, MD (IR)

Parissa Tabrizian, MD (Transplant Surgery)

Reena Salgia, MD (Hepatology panelist)

Lecture 1: "New Combination Data in Context: What Emerging Trials Mean for the Multidisciplinary Treatment Algorithm"

• Speaker: James Harding, MD (Medical Oncology)
• Learning Objective: Interpret emerging combination trial results in the context of the evolving locoregional + immunotherapy evidence base and assess implications for multidisciplinary treatment algorithms, including management considerations for advanced disease presentations.

Lecture 2: "Locoregional Therapy as Adjuvant and Salvage: Optimizing the IR Role in Combination Regimens"

• Speaker: Lindsay Thornton, MD (IR)
• Learning Objective: Evaluate the evidence and clinical rationale for locoregional therapy as both adjuvant and salvage within combination regimens, including patient selection, technique considerations, response assessment (mRECIST), and recognition of treatment futility to guide multidisciplinary sequencing decisions.

Lecture 3: "The Transplant Surgeon's Perspective: Immunotherapy Safety, Downstaging, and Post-Transplant Management"

• Speaker: Parissa Tabrizian, MD (Transplant Surgery)
• Learning Objective: Evaluate transplant-specific considerations in the combination therapy era — including immunotherapy safety and washout in transplant candidates, evolving downstaging criteria, and post-transplant surveillance and management — to optimize multidisciplinary coordination between surgical, medical, and interventional teams

Key Themes:

1. Emerging combination trial data and its place in the evolving treatment algorithm

2. Optimizing locoregional therapy within combination regimens: patient selection, technique, and response assessment

3. Transplant-specific considerations in the immunotherapy era: safety, downstaging, and post-transplant care

4. Bridging the gap between clinical trial populations and real-world practice

5. Multidisciplinary case-based application of emerging evidence